Novo, Pfizer Square Off Over Metsera in Obesity-Drug Tussle

Novo Nordisk A/S made an unsolicited bid for US biotech firm Metsera Inc., sparking a heated battle with Pfizer Inc. to get their hands on weight-loss treatments that both drugmakers want in order to regain lost ground in the booming market.

Novo offered to buy Metsera Inc. for at least $6.5 billion, seeking to trump an earlier agreed deal with Pfizer. Metsera called the new offer, which Bloomberg News reported earlier on Thursday, superior to the previous one from Pfizer that it had accepted last month.

The US drugmaker criticized the attempt to derail its deal as “reckless” and accused its Danish rival of trying to abuse its dominant market position. The move is an effort “to suppress competition in violation of law by taking over an emerging American challenger,” Pfizer said in a statement.

The tussle follows setbacks for both Novo and Pfizer in an obesity market that’s expected to reach $100 billion by 2030. Eli Lilly & Co. has stolen a march on Novo, saying Thursday in an earnings presentation that it now has about 58% of the market for new weight-loss drugs using so-called GLP-1 technology.

Shares of Pfizer were litte changed as of 10:00 a.m. in New York; Novo’s stock is down 2.6%.

The potential rewards from obesity have prompted large drugmakers to snap up smaller companies like Metsera, which has a handful of experimental weight-loss treatments in development, including a shot that could be taken less often than Novo Nordisk’s Wegovy.

Novo “coming in over the top is something that we have rarely seen in pharma, at least as of late,” said Mizuho health-care specialist Jared Holz.

Pfizer's takeover

The jockeying follows a shakeup at the top of Novo, where new Chief Executive Officer Maziar Mike Doustdar is moving aggressively to try to regain the company’s position in an obesity-drug market that it pioneered. Since taking over, he’s announced thousands of job cuts, struck a $5 billion deal for liver disease drugmaker Akero Therapeutics Inc. and said the company needs to execute better on everything it does. The company has also replaced its chairman.

“Novo Nordisk is flexing its muscles,” Per Hansen, an investment economist at Nordnet AB, said by email. “They’re going all in on expanding their pipeline. The consequence is that they’re committing a significant portion of their financial leeway.”